Histone相关论文
目的 体外观察组蛋白脱乙酰基酶抑制剂Panobinostat对前列腺癌细胞系LNCaP、PC-3的X线放射增敏效应,并初步探讨其作用机制.方法 用......
组蛋白去乙酰化酶抑制剂(histone deceatylase inhibitor,HDACi)是一类抑制组蛋白去乙酰化的有机化合物,通过改变组蛋白乙酰化程度......
Spinal cord injury that results in severe neurological disability is often incurable. The poor clinical outcome of spina......
目的建立一种简单、快速、准确地检测人群外周血白细胞中泛素化组蛋白H2B (ubiquityl-histone H2B, ubH2B)修饰水平的方法。方法利用......
目的探索高氟暴露是否会影响外周血组蛋白乙酰化水平,氟骨症患者的组蛋白乙酰化水平是否存在异常,尝试从转录修饰水平上研究氟骨症的......
目的观察砷暴露人群外周血白细胞组蛋白H2AK119泛素化(H2AK119 ubiquitination,H2AK119ub)和H2BK120泛素化(H2BK120ub)修饰水平,分析砷暴......
近年来,地方性砷中毒对免疫系统的影响逐渐引起人们的关注。组蛋白修饰模式的改变可能是砷调控基因表达的机制之一,砷在调节免疫细胞......
目的:建立佛波酯(PMA)诱导人中性粒细胞NETS形成的方法,并研究NETS的结构组成。方法:提取人中性粒细胞,使用10、30、90 n M的PMA分......
期刊
A histone H3K27me3 reader cooperates with a family of PHD finger-containing proteins to regulate flo
Trimethylated histone H3 lysine 27 (H3K27me3) is a repressive histone marker that regulates a va-riety of developmental ......
目的观察组蛋白对小鼠肺组织损伤及血管性血友病因子(vWF)和纤维蛋白原(FIB)水平的影响,并探讨肝素的保护作用。方法将24只6~10周龄雄性C......
...
Heterochromatin Protein 1 (HP1) is a major regulator of chromatin structure and function.In animals,the network of prote......
Study the effects of metallic ions on the combination of DNA and histones with molecular combing tec
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Study the effects of divalent metallic ions on the combination of DNA and histones with fluorescence
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
组蛋白乙酰化修饰是真核细胞基因表达的一种重要调控方式,组蛋白去乙酰化酶作为组蛋白去乙酰化的关键调节酶,在包括肝癌在内的许多......
暴露在核小体表面的N-末端尾部可发生共价修饰,这些共价修饰可以影响组蛋门和DNA结合的紧密程度,从而影响DNA的表达,被称之为"组蛋......
组蛋白去乙酰化酶(histone deacetylases,HDAC)催化组蛋白和非组蛋白去乙酰化,对染色质重构和基因转录有重要的调节作用.而染色质......
目的 研究急性白血病患者组蛋白H3K4和H3K9甲基化及H3、H4乙酰化的修饰异常.方法 用Western blot方法检测19例急性白血病患者组蛋......
慢性阻塞性肺病( chronic obstructive pulmonary disease , COPD)是一种严重影响人类健康的疾病,目前为止发病机制尚不清楚。吸烟导致......
目的:构建人类基因组中16个组蛋白乙酰化酶的短发夹 RNA(shRNA)慢病毒载体文库,为进一步探索表观遗传学基因在 HBV 调控中的作用机制提......
对雌核发育彭泽鲫( Carassius auratus var.Pengze, Pengze crucian carp, Pcc)中的Pcc-hira进行了克隆,序列分析,并对雌鱼9种组织和11个......
Study the effects of metallic ions on the combination of DNA and histones with molecular combing tec
The effects of monovalent (Na+, K+) and divalent (Mg2+, Ca2+, Mn2+) ions on the interaction between DNA and histone are ......
Study the effects of divalent metallic ions on the combination of DNA and histones with fluorescence
The effects of divalent ions (Mn2+, Mg2+, Ca2+) on the interaction between DNA and histone are studied using a fluoresce......
Histone methylation plays crucial roles in epigenetic regulation.The SET domain proteins are now recognized as generally......

